Fitts' Law

Fitts' Law is essential to designing functional pieces that require the user to aim at a target. Don't you just love wikipedia?

From the site:
In ergonomics, Fitts' law (or Fitts's law) is a principle of human movement published in 1954 by Paul Fitts which predicts the time required to move from a starting position to a final target area. The kind of motion it describes is aimed and rapid. The time needed to acquire a target is a function of the distance to the target, and the size of the target. Fitts' law is used to model the act of pointing, both in the real world, e.g. with a hand or finger, and on a computer, e.g. with a mouse.

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